Next-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us?

Next-Generation Sequencing Approaches in Cancer: Where Have They Brought Us and Where Will They Take Us?

Next-generation sequencing (NGS) technologies and data have revolutionized cancer research and are increasingly being deployed to guide clinicians in treatment decision-making. NGS technologies have allowed us to take an "omics" approach to cancer in order to reveal genomic, transcriptomic, and epigenomic landscapes of individual malignancies. Integrative multi-platform analyses are increasingl...

Spreading proteins in neurodegeneration: where do they take us?

Spreading proteins in neurodegeneration: where do they take us? The 'prion-like' nature of neurodegenerative diseases has been mooted for a number of years. The central concept is of self-propagating misfolded proteins spreading from neuron to neuron, associated with more or less stereotypical patterns of neu-rodegeneration in specific diseases. Apart from prion protein (PrP) in the archetypal ...

Universal Grammar and Chaos/Complexity Theory: Where Do They Meet And Where Do They Cross?

  Abstract The present study begins by sketching "Chaos/Complexity Theory" (C/CT) and its applica-tion to the nature of language and language acquisition. Then, the theory of "Universal Grammar" (UG) is explicated with an eye to C/CT. Firstly, it is revealed that CCT may or may not be allied with a theory of language acquisition that takes UG as the initial state of language acquisition for ...

Where will genetic research take us?

Transl Pediatr 2015;4(4):318-319 www.thetp.org When Watson and Crick published the structure of DNA in Nature in 1953, they anticipated that the structure would unlock huge scientific secrets allowing the treatment of a huge range of disorders. In their day, the range of disorders that could have a genetic basis would have been unfathomable and now include forms of cancer, diabetes, Alzheimer’s...

Accountable Care Organizations: What are they? Where are they coming from? Where will they lead?